There are no controlled data in human pregnancy. This talk was sponsored by and given at the headquarters of Mineral Resources International in 2002. Related article: Magnesium Deficiency – Needs for Magnesium Not Met in Most People. In other words, I’m building the case that magnesium deficiency is important in the prevention of eclampsia. In essence, what I will be telling you it is the basic problem is that the maternal magnesium was too low…What I am now saying is that their findings were that low birth weight causes an increase in cardiovascular vulnerability…, To start with, low magnesium levels are characteristic of pregnancy-induced hypertension, which is the beginning of eclampsia, the beginning of toxemias of pregnancy, and full-blown eclampsia. That is extremely important, because the typical intake of magnesium is inadequate…  It has been shown that, at the very least, three-quarters of the American population are deficient in magnesium, and when it’s a pregnant woman, that’s bad news. Shechter’s work showing that oral magnesium treatment— not the intravenous— caused less platelet dependent thrombosis in heart disease. When the level of magnesium in the body drops below normal, symptoms develop due to low magnesium. The researchers reasoned that it was related to malnutrition, including a low protein and high carbohydrate/fat diet. What does that mean for the cardiovascular system?…What we know is that when you put experimental animals, regardless of the species (rodents, chicks, calves, pigs, dogs right up to monkeys, every one of them) on a low magnesium intake when they are very young, they get severe arterial lesions, and those arterial lesions resemble those that have been detected on autopsy of stillborn infants and those dead in the first month through the first two and a half years of life. Magnesium is also used as what we call an assist to tocolytic treatment. The heart damage in infants that were stillborn or dead in the first month includes myocardial necrosis, cell infiltration, fibrosis, and calcification. (Paraphrased for clarity) A favorite news clipping I have seen is of a golden wedding anniversary that was attended by both parents of the bride. And, if you look at areas in Norway,  they went up as high as 688 milligrams a day of magnesium from their diet and they retained as much as l66 milligrams a day of magnesium. Hypomagnesemia was significantly correlated with the occurrence of pre-eclampsia ( P = 0.011), leg cramps ( P = 0.000) and pre-term birth ( P = 0.030). A Higher Concentration of Dialysate Magnesium to Reduce the Frequency of Muscle Cramps: A Narrative Review. Headers have been added. Two other regions were studied and reported about two years ago in East Serbia and North Serbia. They give them calcium and vitamin D, which intensifies the risks to the cardiovascular system. Would it shock you if I told that there have been reports of babies developing myocardial infarction before they were born? Both in Hungary and in Germany, they found that magnesium being given to pregnant women had very beneficial results in that the babies were bigger, they didn’t have per-term birth, and the pregnancy was extended to a normal period instead of the babies being born early. This article is pulled from a talk by the late Dr. Mildred Seelig, who was perhaps the world’s most preeminent researcher on Magnesium. Supplemental magnesium does not appear to effect the incidence of preterm birth or perinatal mortality. Magnesium oils and body butters infused with magnesium are great for quick and immediate skin relief, as are magnesium flakes added directly to a warm bath. Low magnesium levels don't cause symptoms in the short term. Epub 2012 Jul 6. So, I raise the question—might low magnesium and the calcium content of the diet…be a factor in early low birth weight? Would you care to guess? BJOG. These are babies stillborn or dead in the first month! Related: Mineral Resources International – 50 Years of Improving Global Health. ... Low magnesium intakes for a long period of time, however, can lead to magnesium deficiency. So these people live long, even though they had risk factors. Early antenatal serum lipid levels and the risk of pre-eclampsia in Trinidad and Tobago. Subjects and methods: 2720 Wadman Drive It favorably affects… endothelium factors. (Paraphrased) So, in 1995, there was a big multi-institution study reported in which…they discovered that Zuspan was right—magnesium was the best. So, they thought that estrogen would reduce the risk, but it was actually increasing it. This includes the physical and chemical processes in the body that convert or use energy ( metabolism ). There are no controlled data in human pregnancy. What do you think the recommendation of the organization to which we look for our advice (the National Academy of Science Food and Nutrition board) as to how much we should eat? Nutr Rev. Shechter’s work showing that oral magnesium treatment— not the intravenous— and that, of course, is of interest to you and your group, caused less platelet dependent thrombosis and this is in heart disease. And now I’m going to tell you something even worse! Therefore, opt magnesium supplements as a last resource. Objective: So I’ve had to go to the basic work on the heart which is pertinent. In countries intake of magnesium during pregnancy is low, both the women and babies experience higher risks. Now, I’m going to show you what the current recommendations are, again, is one of the things that I’m unhappy about. But, they did undertake a small study and found that when they provided magnesium supplement starting in the first trimester (very much like a Hungarian study) they had larger babies. Dalton LM, Ní Fhloinn DM, Gaydadzhieva GT, Mazurkiewicz OM, Leeson H, Wright CP. 400 milligrams. Magnesium and Health. Chronic low levels of magnesium could cause potassium and calcium levels to fall. J Assoc Physicians India. I’m going to refer to the effect of magnesium in heart disease because there hasn’t been as much work on how the mechanisms by which magnesium protects against the damage to the placenta and to the mother when she has eclampsia. BRAzil magnesium (BRAMAG) trial: a double-masked randomized clinical trial of oral magnesium supplementation in pregnancy. Skin Health – If you suffer from acne or redness, sometimes rashes on the parts of the body … Then, I undertook another study…And i the years from 1991 to 1998…so it’s not over—we’ve still got it. 2016 Sep;74(9):549-57. doi: 10.1093/nutrit/nuw018. In the last three months of pregnancy, the embryo stores up to … eCollection 2020. de Araújo CAL, Ray JG, Figueiroa JN, Alves JG. However, the same can't be said for supplements. I found this paper written by epidemiologists where they made a very important observation. But first, a quick refresher on why you may need to take magnesium while pregnant. So you’re seeing to it that she herself is healthier and the placenta is not attacked. Something occurred to me: What would be sensible to figure out is, what in the mother caused low birth weight? Serum magnesium has been shown to decrease in pregnancy, 33 but this may be due in part to hemodilution. Osteoporosis is a disorder characterized by weak bones and an increased risk … Therefore, opt magnesium supplements as a last resource. 2020 Apr 11;34:32. doi: 10.34171/mjiri.34.32. That’s what gives you strokes and heart attacks and damage for the people who have diabetes results in the damage to the legs that results in them having their legs amputated. Doyle, Crawford, Wynn and Wynn in the 1980s, made the observation that a little over 7 percent of British babies are born under 2,500 grams. And the affected arteries were the larger arteries, and they were calcified—just like you see in adults. This protects her from…severe damage to the heart that occurs very shortly after birth… You’re keeping the mother in a better state. Dr. Mildred Seelig’s forty years of research established her as one of the world’s foremost magnesium researchers and reviewers. Myocardial infarction in utero is not rare but it’s usually missed because it involves the terminal arterials that are just under the endocardium. MRI is a family-owned and operated business (well into its third generation) and is a source of pride for us. Magnesium supports a healthy pregnancy in various ways. 2018 Jun;11(2):67-72. doi: 10.1177/1753495X17744478. And what do they recommend? That is very important and I’ll show you why. They took electrocardiograms through the mother’s abdomen and found that the babies had had arrhythmias…. Studies suggest links … Prevention and treatment information (HHS). As a result, there was a fashion for a short period of time, thank goodness, that when a man got a heart attack, what did some of the doctors do? Prediction of preterm labor by the level of serum magnesium using an optimized linear classifier. That’s shocking…, Because the mother was having difficulty, the baby was obviously having trouble. Magnesium is thought to help constricted blood vessels within the brain to relax and prevent the buildup of lactic acid that contributes to tension and worsens migraine pain. This is classic, everybody knows this. This happens to people who have damaged kidneys , or take certain drugs . So…that first step of clotting doesn’t take place in the artery—and you don’t want it to take place in the artery. But the English have a problem with magnesium while 99 percent of the American physicians treated women with magnesium after they read this work from Zuspan and then the German work. Pre-eclampsia and pre-term birth are associated with hypomagnesemia in pregnancy; hence, magnesium supplementation or magnesium-rich diet consisting of green leafy vegetables, soy milk and legumes may improve outcome. I suggest that low maternal magnesium is an important clue to solve first the mystery of low birth weight. Magnesium level is known to decline during pregnancy. What these people developed was that the survivors of low birth weight had a high incidence of hypertension, arterial sclerosis, heart disease of all sorts, dyslipidemia (that’s a high blood cholesterol) hypercoagulability of the blood, and diabetes or insulin resistance. Presented by Mineral Resources International (MRI) from a sponsored talk given at headquarters in Ogden, Utah in 2002. 2018 May 29;2018:4843159. doi: 10.1155/2018/4843159. This is one of the earliest and most common symptoms of a magnesium deficiency. In Serbia, they have an almost built-in study, which indicates what I’ve been telling you is right…In West Serbia, their water was very high in magnesium and the calcium…was very low, and the cardiovascular disease mortality rate was extremely low. Influence of mineral and vitamin supplements on pregnancy outcome. 2020 Oct 22;7:2054358120964078. doi: 10.1177/2054358120964078. Generally, magnesium works in combination with calcium. Concentrated Mineral Drops. Anderson Sea M.D. Epub 2018 Mar 7. The life-threatening pregnancy complication preeclampsia is associated with a magnesium deficiency, and the same goes for gestational hypertension, as well as leg cramps and water retention. It has long been known (since 1925) that magnesium, intravenously, is a very good treatment to treat eclampsia. These were really the normal hearts, but they had these infarcts and the babies died. I think that’s shocking because all the data were there, but they wouldn’t read it or didn’t believe it. Epub 2012 Jan 18. Their sociodemographic and clinical characteristics were used to generate a database for analysis. What they found was that in Germany, Finland, the United States, and Norway, there was an enormous range of what the women actually took in, in the form of magnesium from their food. He said,  “I couldn’t find any explanation. Tocolysis is what you give to a woman who has threatened pre-term birth, when the uterus clamps down and it tries to expel the baby. Magnesium counteracts the coagulation cascade…that is increased by both estrogen and calcium. Although a balanced diet usually supplies all the magnesium a person needs, magnesium supplements may be needed by patients who have lost magnesium because of illness or treatment with certain medicines. Clipboard, Search History, and several other advanced features are temporarily unavailable. Frightening isn’t it? There was no maternal mortality or early neonatal death. Osteoporosis. Conditions that may be associated with abnormal magnesium levels include diabetes and kidney disorders. Clinical significance of low serum magnesium in pregnant women attending the University of Benin Teaching Hospital However, chronically low levels can increase the risk of high blood pressure, heart disease, type 2 diabetes and osteoporosis. 2011 Oct;117(4):215-21. doi: 10.3109/13813455.2010.543137. Extensive metabolic balance studies have shown that the ideal ratio is 2 to 1 of calcium to magnesium; they’ve got close to 3 or 4 to 1. They reduced the pre-term birth from control of 11 percent to 8-and-a-half percent. (Edited for clarity) I’ll give you another sad story about estrogen. The full transcript of her talk is technical and references many sources, and you can read it by reaching out to us. High levels of magnesium are much less common than low levels. Now, Bonar, in England in 1971, showed that the thrombotic placental damage actually contributes to eclampsia…and basically, this is part of the reason that magnesium protects against low birth weight. To start with, low magnesium levels are characteristic of pregnancy-induced hypertension, which is the beginning of eclampsia, the beginning of toxemias of pregnancy, and full-blown eclampsia. Fatigue. Do you remember the actress Patricia Neal? Maybe that was it. you might have trouble absorbing magnesium from food if you drink too much alcohol, have kidney problems, take certain medicines, or have celiac disease or long-lasting digestive problems.. You get thrombosis that’s caused by magnesium deficiency which damages the placenta and impairs the blood flow to the fetus. We’ll explain the different types of magnesium you can take during pregnancy. A magnesium deficiency can kill your appetite and make you feel tired and weak. Studies are clear that magnesium chloride is an essential mineral and plays an important role in both maternal and fetal health during pregnancy. So, if you have a high calcium to magnesium ratio, there’s a real risk that you will activate coagulation in the arteries. 1998 to 2000, the latest recommendations by the people who are supposed to know (the National Academy of Science, the Food and Nutrition Board, and the Institute of Medicine) recommend a ratio of 310 to 320 milligrams of magnesium (I’m just talking about the women at this point) and calcium at 1000 to 1200. You don’t want it to do that when it’s too early, so what they do is they give drugs… They found that they markedly improved the outcome and reduced the amount of tocolytic drugs that they needed by giving magnesium… so the baby is now more likely to be closer to the normal size at birth. She finally came back. This site needs JavaScript to work properly. So, I’ve had to go to the basic work on the heart, which is pertinent. On the flip side, there are many benefits of having a rich intake of magnesium during pregnancy. (Paraphrased) Researchers conducted a study which showed that babies born with low birth rate had a higher risk for early cardiovascular disease and more risk factors than those born with normal birth weight. So I’m giving you some scare data but in the baby, for the baby, it damages the placenta.  |  Research suggests that getting adequate magnesium during pregnancy can help prevent the uterus from contracting prematurely. (801-731-7040). The following article is written from excerpts that were transcribed from Dr. Seelig’s talk, with intermittent paraphrasing, slight rewording for clarity from the spoken word, or abbreviating as noted. I’m going to remind about something which you may not remember. So what does the magnesium do to the mother that’s good? Magnesium sulfate readily crosses the placenta and may produce hypotonia and hypotension; fetal serum concentrations approximate those of the mother. They were pathologists who said (and listen to this comment). A colleague saw this and was curious as to why. Inadequate magnesium intake by the mother is under 500 milligrams of magnesium a day. Hawkins TL, Roberts JM, Mangos GJ, Davis GK, Roberts LM, Brown MA. Low magnesium is typically due to decreased absorption of magnesium in the gut or increased excretion of magnesium in the urine. Magnesium is used as a dietary supplement for individuals who are deficient in magnesium. The babies who lived or didn’t die until over one month to 2½ years also had very comparable arterial and myocardial lesions, but the lesions here were bigger. During pregnancy, the demand for magnesium increases. We call that the NIH phenomenon— if it’s Not Invented Here, it’s no good. So, we’re on the right track. Magnesium is a mineral that your body requires to form bone, protein and fatty acids. Low magnesium levels in otherwise healthy people are uncommon. Magnesium also helps build strong teeth and bones in your baby. In MAGNESIUM IN PREGNANCY The requirements of magnesium in pregnancy are not well understood. Aminimoghaddam S, Barzin Tond S, Mahmoudi Nahavandi A, Mahmoudzadeh A, Barzin Tond S. Med J Islam Repub Iran. eCollection 2020. Pre-eclampsia and pre-term birth are associated with hypomagnesemia in pregnancy; hence, magnesium supplementation or magnesium-rich diet consisting of green leafy vegetables, soy milk and legumes may improve outcome. Chronically low levels of magnesium have been linked to diabetes, high blood pressure, heart disease, sudden cardiac death, migraines, menstrual cramps, depression, osteoporosis, and asthma. Magnesium is needed for many functions in the body. Magnesium is found naturally in many foods and is added to some fortified foods. Now this, I think is an important observation, and I’m building the case that magnesium deficiency is important in the prevention of eclampsia.

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